Sarcopenia
Conditions
Interventions
The non-sarcopenia group:None
Sponsors
The Seventh Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years, no gender restrictions. 2. Patients scheduled to undergo elective lower limb orthopaedic surgery within the next 3–12 months. 3. Conscious and able to comprehend the study content and independently sign the informed consent form, or have consent from their legal representative. 4. Able to cooperate with relevant examinations including muscle strength and physical function assessments. 5. Body Mass Index (BMI) range: 18.5 kg/m² <= BMI < 35.0 kg/m², to exclude extreme effects of malnutrition or severe obesity on muscle metabolism.
Exclusion criteria
Exclusion criteria: 1. Conditions severely affecting muscle physiology or function: such as uncontrolled hyperthyroidism/hypothyroidism, Cushing's syndrome, severe chronic kidney disease (eGFR 3 months) oral or injectable glucocorticoid therapy or other medications known to affect muscle mass. 5. Malnutrition, cachectic state. 6. Patients undergoing orthopaedic emergency surgery. 7. History of alcohol or substance abuse. 8. Inability to complete necessary baseline assessments or refusal to provide muscle samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle tissue transcriptomes, proteomes ;blood metabolomes;faecal metagenomic; | — |
Countries
China
Contacts
Public ContactFan Xia
The Seventh Affiliated Hospital Sun Yat-sen University
Outcome results
None listed