Anxiety Disorder (Preoperative)
Conditions
Interventions
Group M:Preoperative intravenous injection of midazolam
Group E:Preoperative intravenous administration of esketamine
Sponsors
Zhongshan People’s Hospital(Affiliated Zhongshan Hospital of Sun Yat-sen University)
Eligibility
Sex/Gender
Female
Age
18 Years to 44 Years
Inclusion criteria
Inclusion criteria: 1.Females, 18 to 44 years of age; 2.ASA physical status I-II, scheduled for day-case hysteroscopic endometrial lesion resection or loop electrosurgical excision procedure (LEEP); 3.Voluntary participation in this clinical trial and provision of written informed consent; 4.BMI: 18-30 kg/m^2;
Exclusion criteria
Exclusion criteria: 1.Amsterdam Preoperative Anxiety and Information Scale (APAIS) anxiety subscore 100 beats per minute, or history of any other cardiac arrhythmia; 4.Poor comprehension, psychiatric disorders, or central nervous system disturbances that would preclude cooperation; 5.History of severe cardiac, cerebrovascular, respiratory, hepatic, or renal disease; 6.Hypertension, intracranial hypertension, glaucoma, or untreated/poorly controlled hyperthyroidism; 7.Pregnant or lactating women; 8.Perimenopausal or postmenopausal women (defined as: age >= 45 years and amenorrhea for >=12 months); 9.History of alcohol or opioid substance abuse, or chronic use of sedative or anticonvulsant medications; 10.Unwilling to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analog scale for anxiety,VAS-A; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numerical Rating Scale, NRS;Total Hospitalization Cost;Total Length of Hospital Stay;Incidence of Perioperative Drug-Related Adverse Events;Athens Insomnia Scale, AIS;Quality of Recovery-15 score,QOR-15;Ramsay Sedation Scale; | — |
Countries
China
Contacts
Public ContactXiaozu Liao
Zhongshan People’s Hospital(Affiliated Zhongshan Hospital of Sun Yat-sen University)
Outcome results
None listed