Postoperative Fatigue
Conditions
Interventions
propofol group (Group P):Anesthetic induction: Administer sufentanil 0.4~0.6 µg/kg and propofol 1.5~2.5 mg/kg intravenously. Following loss of the eyelash reflex, administer rocuronium bromide 0.6 mg/
sevoflurane group (Group S):Anesthetic induction: Pre-fill the anesthesia circuit with 8 vol% sevoflurane for 30 seconds. Instruct the patient to take a deep breath, hold their breath after one maxima
remimazolam group (Group R):Anesthetic induction: Intravenous injection of 0.4~0.6 µg/kg sufentanil and 0.2~0.3 mg/kg remimazolam tosylate (bolus over >30 seconds). Following disappearance of the eyel
Sponsors
Baotou Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old; 2. ASA classification I-II; 3. Planned to undergo elective laparoscopic total hysterectomy under general anesthesia with an expected surgery duration of more than 1 hour; 4. BMI: 18.5-24 kg/m²; 5. Patient is informed, consents voluntarily to participate in this study, and signs the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients undergoing emergency surgery within 24 hours of admission; 2.Patients with preoperative fatigue, defined as a score >24 on the International Consultation on Incontinence Questionnaire-Fatigue Scale (ICFS-10), a score =6 on the Christensen Fatigue Scale, or a score =16 on the Chalder Fatigue Questionnaire; 3.Patients with poor preoperative comprehension, communication barriers (speech disorders, mental abnormalities), or poor compliance and cooperation; 4.Patients with preoperative cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score of 1.5 mg/dL); 6.Patients with alcohol addiction or regular use of sedatives or analgesics; 7.Patients with an expected postoperative cardiovascular event risk >5% (based on the Revised Cardiac Risk Index); 8.Patients with poor pulmonary function (carbon monoxide diffusing capacity <40% or forced expiratory volume in one second <40%); 9.Patients with preoperative anemia, hyperthyroidism, primary hyperparathyroidism, or other endocrine and metabolic disorders; 10.Patients with autoimmune diseases; 11.Patients who have recently used hormones, immunosuppressants, or received radiotherapy or chemotherapy; 12.Patients who have undergone surgery under general anesthesia within the past year; 13.Patients with known allergies to any drugs or foods; 14.Patients with preoperative infections or fever; 15.Patients who have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Fatigue incidence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Triceps Brachii Skinfold Thickness;grip strength;Neutrophil-to-lymphocyte ratio; | — |
Countries
China
Contacts
Public ContactCao Ruonan
Baotou Central Hospital
Outcome results
None listed