Severe hypoxemia, bilateral pulmonary infiltrates, respiratory failure requiring mechanical ventilatio
Conditions
Interventions
Extended Prone Position Ventilation Group:Extended prone position ventilation strategy
Conventional Prone Position Ventilation Group:Conventional prone position ventilation strategy
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Diagnosis of moderate-to-severe ARDS (Berlin criteria: PaO2/FiO2 =0.6 and PEEP >= 5 cmH2O); 3.Requiring invasive mechanical ventilation with expected duration >= 48 hours; 4.Identified as "oxygenation responder" after the first 16-hour prone session; 5.Written informed consent obtained from the participant or legal guardian.
Exclusion criteria
Exclusion criteria: 1.Pregnancy or lactation; 2.Contraindications to prone positioning (spinal instability, severely increased intracranial pressure, severely increased intra-abdominal pressure, hemodynamic instability); 3.Cumulative prone positioning ventilation >= 48 hours prior to this ICU admission; 4.Expected survival < 48 hours; 5.Currently receiving extracorporeal membrane oxygenation (ECMO) support.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day ventilator-free days (VFD-28); | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to successful liberation from invasive mechanical ventilation; | — |
Countries
China
Contacts
Public ContactChen Zhongqing
Southern Medical University Southern Hospital
Outcome results
None listed