aortic intramural hematoma (IMH)
Conditions
Interventions
Observation group:None
Sponsors
ZhongShan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Meet all the following criteria: 1. Age >=18 years; 2. Intramural aortic hematoma thickness >5 mm; 3. Hemodynamically stable at presentation, with no indications for emergency surgery; 4. Informed consent has been obtained; 5. Acute onset <=14 days, diagnosed as a Stanford Type B intramural aortic hematoma;
Exclusion criteria
Exclusion criteria: Meet any one of the following criteria: 1.Initial CTA at presentation shows involvement of the ascending aorta; 2. Complex IMH presenting with hemodynamic instability at initial presentation, requiring urgent surgical intervention; Diagnostic criteria for complex IMH are based on the 2024 ESC guidelines and include meeting any one of the following: (1) Aortic rupture; (2) Symptoms of visceral, lower extremity, or spinal cord ischemia; (3) Periaortic hematoma; (4) Rapid enlargement of the aortic diameter; (5)Recurrent pain or uncontrolled hypertension despite optimal medical therapy; 3. Concurrent connective tissue disease, such as Marfan syndrome; 4. Rheumatic or immunological disorders involving the aorta; 5. History of aortic disease treated with aortic endovascular stent graft implantation; 6. Severe cardiac, pulmonary, or hepatic failure; 7. Severe renal failure (creatinine > 250 µmol/L) not on dialysis; 8. History of active malignant tumors; 9. Life expectancy of less than 1 year; 10. Inability to undergo or tolerate CTA examinations during follow-up due to factors such as contrast agent allergy; 11. Requirement for long-term oral anticoagulants (e.g., warfarin) due to other medical conditions; 12. Women of childbearing potential who have tested negative for pregnancy but refuse to use effective contraception, or women who are pregnant or breastfeeding; 13. Participation in or ongoing enrollment in a clinical trial of a drug or medical device within the past 30 days; 14. History of severe drug or alcohol abuse within the past year; 15. Conditions deemed unsuitable for participation in this study by the investigators, such as mental illness, cognitive or emotional disorders that prevent understanding or compliance with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| aoritc adverse events; | — |
Countries
China
Contacts
Public ContactDong Zhihui
ZhongShan Hospital Fudan University
Outcome results
None listed