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ß-? cross-frequency coupling tACS regulate the M1 excitability to improve upper-limb motor function of stroke survivors: a double-blinded, sham-controlled, randomized controlled trial

ß-? cross-frequency coupling tACS regulate the M1 excitability to improve upper-limb motor function of stroke survivors: a double-blinded, sham-controlled, randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600120914
Enrollment
Unknown
Registered
2026-03-23
Start date
2026-03-29
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Sham-stimulation group:CRP for upper limb motor recovery post-stroke will be employing a multi-modal approach centered on neuroplasticity, which will be included passive and active limbs movement, pro
ß-stimulation group :Routine rehabilitation training+ß - TACs, 20min+20min. The routine rehabilitation training was the same as the above group. TAC was provided by neuroconn DC stimulator through a p
Duration: 20 minutes (including 30 second climb/descent)
Current intensity: 1.0 Ma peak to peak, 0.02857 ma/cm 2
Skin preparation and impedance monitoring will ensure that the impedance is<10 K O
the stimulation frequency is 20Hz.
?-stimulation group:Routine rehabilitation training+ß - TACs, 20min+20min. The routine rehabilitation training was the same as the above group. TAC was provided by neuroconn DC stimulator through a pa

Sponsors

Shanghai Municipal Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) the clinical diagnosis was cerebral hemorrhage or cerebral infarction confirmed by CT / MRI; (2) 45-75 years old; (3) the first-ever stroke, and the time of since stroke onset 24); (6) signed informed consent.

Exclusion criteria

Exclusion criteria: (1) Diagnosis of any other neurological conditions, including depression, severe language comprehension deficits, unilateral spatial neglect, epilepsy, upper-limb apraxia, etc.; (2) With any active uncontrolled cardiovascular, or orthopedic condition; (3) Exhibit substantial peripheral neuropathy in the upper limb; (4) Had severe shoulder pain or wrist and finger contractures; (5) Implanted metal in the head or implanted cardiac pacemaker; (6) Combined with some contraindications to tACS and Transcranial Magnetic Stimulation (TMS); (7) Currently participating in any other clinical study or coach directed exercise program

Design outcomes

Primary

MeasureTime frame
Upper-limb motor function ;Incidence rate of adverse events;

Secondary

MeasureTime frame
Corticospinal excitability;Corticomuscular coherence;

Countries

China

Contacts

Public ContactBeiying Qin

Shanghai Municipal Hospital of Traditional Chinese Medicine

334513641@qq.com+86 137 6447 9932

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 4, 2026