Non-small cell lung cancer
Conditions
Interventions
Observation Group:None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old. 2. Pathological diagnosis of stage II-IIIB non-small cell lung cancer by percutaneous lung puncture or bronchoscopic biopsy. 3. Received standard neoadjuvant therapy before the operation and completed at least 2 cycles. 4. Underwent radical lung cancer resection after neoadjuvant therapy and had a complete postoperative pathological assessment report. 5. Have high-quality chest CT image data before neoadjuvant therapy. 6. Digital pathological sections of tumor tissue biopsies before neoadjuvant therapy are available.
Exclusion criteria
Exclusion criteria: 1. Received other anti-tumor treatments before neoadjuvant therapy. 2. Incomplete clinical, imaging or pathological data cannot meet the requirements for model construction. 3. Suffering from other active malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-neoadjuvant pathological response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical variables: age, gender, smoking history, clinical TNM stage, pathological type, PD-L1 expression level (TPS/CPS), hematological markers (such as tumor markers, etc.);Radiomics features: Extracted from baseline chest CT images before neoadjuvant therapy. Three-dimensional delineation of the primary tumor was performed on arterial phase images, and thousands of quantitative features (including first-order statistics, shape features, texture features, and wavelet signs) were extracted using dedicated software.;Pathological image features: Digital scanning of HE staining sections of biopsy tissues before neoadjuvant therapy is conducted to generate full section digital images.; | — |
Countries
China
Contacts
Public ContactXia Guojin
The First Affiliated Hospital of Nanchang University
Outcome results
None listed