Upper limb dysfunction in stroke
Conditions
Interventions
Bilateral Group (Bilateral Vagus Nerve Stimulation Group):30-minute bilateral vagus nerve stimulation before task-oriented training (Bilateral Vagus Nerve Stimulation Group)
electrodes placed at the cavum conchae and cavum antitragus
stimulation parameters: 0.3ms square pulse, 20Hz frequency, 30 seconds duration, repeated once per minute
current intensity set to patients maximum tolerable level
once daily, five times per week for four weeks.
Unilateral Group (Unilateral Vagus Nerve Stimulation Group):30-minute unilateral vagus nerve stimulation before task-oriented training (Unilateral Vagus Nerve Stimulation Group)
electrode placed on the left ear (cavum conchae)
Sham Stimulation Group (Control Group):Place electrodes (at both cavum conchae and cavum antitragus) and perform sham stimulation without electrical output
Sponsors
Shandong Second Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 80; 2. Stroke is diagnosed by a clinical doctor in accordance with the guidelines of the "Chinese Stroke Prevention and Treatment Guidelines"; 3. The first occurrence of ischemic or hemorrhagic stroke, with a course of more than 2 weeks but less than 1 year, and stable vital signs; 4. Unilateral hemiplegia of the upper limb, Brunnstrom stage III or above; 5. Have the ability to give informed consent and understand instructions.
Exclusion criteria
Exclusion criteria: 1. Having implanted devices such as a cardiac pacemaker; 2. Presence of abnormal skin conditions that may interfere with stimulation or the stimulation device, such as scar tissue or damaged skin; 3. Previous vagus nerve injury; 4. Upper limb dysfunction caused by reasons other than stroke; 5. Severe heart dysfunction or heart disease; 6. Injection of botulinum toxin within the past 3 months; 7. Use of antidepressants or benzodiazepines.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment Upper Extremity Scale;Concentration of cerebral oxygenated hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Ashworth scale;Box and Block Test;Hospital anxiety and depression scale;Grip strength and pinch strength test; | — |
Countries
China
Contacts
Public ContactLiu Hao
Shandong Second Medical University
Outcome results
None listed