Degenerative diseases of the lumbar spine
Conditions
Interventions
Tranexamic acid group:On the evening prior to surgery at 22:30, administer 2 ml of normal saline solution by intramuscular injection. Fifteen minutes before skin incision, administer TXA at 15 mg/kg b
Bachu Ting Group:On the evening prior to surgery at 22:30, administer 1U of bacitracin (powder, 1U/vial) + 2ml saline solution by intramuscular injection. Fifteen minutes before skin incision, adminis
Sponsors
West China Tianfu Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with severe intervertebral disc protrusion, lumbar spinal canal stenosis, symptomatic lumbar spondylolisthesis, etc., who need to undergo TLIF surgery and are first-time patients who have undergone lumbar surgery; 2. Patients aged 18 years or older and 80 years or younger; 3. Patients agree to participate in this study and sign the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe underlying diseases such as cardiovascular and cerebrovascular disorders who are not suitable for surgery; 2. Patients with severe anemia or coagulation dysfunction before the operation; 3. Patients allergic to TXA or batroxobin; 4. Patients with severe liver or kidney dysfunction; 5. Patients with a history of thrombosis; 6. Patients who are still taking anticoagulant drugs (such as aspirin) within two weeks before the operation; 7. Patients with intraoperative dural injury and cerebrospinal fluid leakage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TBL on the first, second and third days post-surgery;Intraoperative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative occult blood loss;Postoperative fibrinolysis and inflammatory markers;Total postoperative drainage volume;Postoperative hospital stay duration;Postoperative complications; | — |
Countries
China
Contacts
Public ContactLiu Li
West China Tianfu Hospital, Sichuan University
Outcome results
None listed