Colorectal cancer
Conditions
Interventions
Experimental group:Abdominal Transversus Plane Block Performed with Hydrocodone and Ropivacaine
Sponsors
Yibin Second People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. All participants provided written informed consent; 2. Aged 45 to 75 years; 3. American Society of Anesthesiologists (ASA) physical status classification I to III; 4. Scheduled for elective laparoscopic radical resection of colorectal cancer with an expected surgical duration of >=120 minutes; 5. Preoperative Barthel Index score =95.
Exclusion criteria
Exclusion criteria: 1. Patients with a confirmed preoperative diagnosis of dementia, a history of psychiatric disorders, or long-term use of antipsychotics or sedative-hypnotics; 2. Patients with a history of long-term opioid use, a history of drug/alcohol abuse, or addiction; 3. Patients with a history of stroke, sequelae of traumatic brain injury, severe cardiac, pulmonary, hepatic, or renal insufficiency, or coagulation disorders; 4. Patients with known allergies to the study drugs (hydromorphone, ropivacaine) or any other medications used during anesthesia; 5. Patients who received neoadjuvant radiotherapy, chemotherapy, targeted therapy, or other anti-tumor treatments prior to surgery (radiotherapy and chemotherapy are strong confounders for cognitive impairment); 6. Patients with severe hearing or visual impairments that prevent them from cooperating with the completion of the scale assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative neurocognitive disorders (PND); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination (MMSE) score;Resting Visual Analogue Scale (VAS) pain score;Cumulative number of tramadol use after surgery;mean arterial pressure (MAP) ;Heart rate (HR);Time to first ambulation after surgery;Time to first flatus after surgery;Barthel Index score;Montreal Cognitive Assessment (MoCA) score ;15-Item Quality of Recovery Scale (QoR-15) score; | — |
Countries
China
Contacts
Public ContactYi Chuanyun; Yu Deshui
Yibin Second People's Hospital
Outcome results
None listed