esophagus cancer
Conditions
Interventions
1:Nutrition plan: Oral retinol (vitamin A soft capsules, 5000 units per day) and nicotinamide precursor supplement [nicotinamide mononucleotide (NMN) (300 mg per day)].
2:CBT-I program: A 5-week structured insomnia cognitive behavioral therapy, including sleep hygiene education, stimulus control, sleep restriction, cognitive restructuring and relaxation training.
3:Combined program: The nutrition plan is implemented in conjunction with the CBT-I program.
4:Control group: Received routine care and health education for tumor radiotherapy.
Sponsors
The Second Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.According to the diagnostic criteria of the World Health Organization (WHO),esophageal squamous cell carcinoma was confirmed by tissue biopsy; the clinical stage was determined in accordance with the 8th edition of the American Joint Committee on Cancer staging manual. 2.Age >= 18 years old. 3.Planned to receive radical radiotherapy. 4.No cognitive impairment, and able to independently complete the questionnaire filling.
Exclusion criteria
Exclusion criteria: 1.Having received previous chest radiotherapy. 2.Having communication or comprehension difficulties. 3.Currently participating in other clinical intervention studies. 4.Long-term use of VA/VB3/NAD^+ supplements. 5.Having severe liver or kidney dysfunction or sleep apnea syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh sleep quality index;PROMIS Sleep Disturbance 8a;PROMIS Sleep Related Impairment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cancer Fatigue Scale;Quality of Life Questionnaire Core 30;Patient-Generated Subjective Global Assessment;Upper limb muscle strength;Lower limb muscle strength and endurance;Balance and mobility skills; | — |
Countries
China
Contacts
Public ContactZhao Xia Yang
The Second Affiliated Hospital of Shandong First Medical University, Tai'an City, Shandong Province
Outcome results
None listed