Tissue necrosis after Naja atra (Chinese cobra) bite
Conditions
Interventions
Conventional Treatment Group:Conventional Debridement + Intravenous Antivenom Therapy
Combined Treatment Group:Early Radical Debridement + Negative Pressure Drainage + Local Antivenom Infiltration+ Intravenous Antivenom Therapy
Sponsors
Wenzhou People‘s Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 14–85 years, time from snakebite to first hospital visit <= 24 hours; 2. Confirmed bite by Chinese cobra (Naja atra) with on-site or imaging evidence; 3. Local necrosis Grade ?–? (according to the 2018 Chinese Snakebite Classification Standard); 4. Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Necrosis >= Grade ?, or emergency amputation required due to complicated compartment syndrome; 2. Pregnancy/lactation, severe hepatic or renal insufficiency, coagulation dysfunction, immunodeficiency; 3. History of severe allergy to antivenom or negative pressure drainage materials; 4. Extensive debridement or skin grafting performed before referral; 5. Mental disorders or poor compliance unable to complete follow-up; 6. Simultaneous participation in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of change in necrotic tissue volume at 7 days post-treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to complete wound epithelialization; | — |
Countries
China
Contacts
Public ContactChenghao Zhang
Wenzhou People‘s Hospital
Outcome results
None listed