Patients with WD hepatic type, 5WD cerebral type patients
Conditions
Interventions
WD hepatic group:None
Normal Control Group:None
WD Neurological group:None
Sponsors
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Wilson's Disease Group (WD) : 1. All WD patients must have a Leipzig score >= 4 points. 2.? Grouping method: Patients are classified by senior neurologists (attending physicians or higher) based on clinical manifestations into ?hepatic type? (predominant liver impairment) or ?neurological type? (predominant brain damage). Normal Control Group ?Criteria: Healthy controls matched with WD patients in terms of sex, age, and education level. ?Additional requirements: Aged 18–30 years; Right-handed; No history of neurological or psychiatric disorders.
Exclusion criteria
Exclusion criteria: 1. Severe neuropsychiatric symptoms; 2. Eligible patients with severe liver disease (Child-Pugh score of D); 3. The amplitude of head movement is too large to cooperate with the completion of MRI examination; 4. Those who are contraindicated to MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting-state head MRI;specificity;sensitivity;Area under the ROC curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate, Blood Pressure;Kayser-Fleischer (K-F) Rings; | — |
Countries
China
Contacts
Public ContactYunfan Wu
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Outcome results
None listed