None
Conditions
Interventions
Group A:Nasal administration of dexmedetomidine+butorphanol tartrate group
Group B:Physiological saline placebo+butorphanol tartrate group
Group D:Physiological saline placebo+sufentanil group
Group C:Dexmedetomidine administered via nasal route+sufentanil group
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old; 2. There was no cognitive impairment before surgery (preoperative Montreal Cognitive Assessment Scale (MoCA) score >=26 points); 1.Mini Mental State Examination (MMSE) score >= 23 points; 3.The patient's physical classification is from grade I to grade III. According to the American Society of Anesthesiologists Physical Status Classification (ASA), the patient is physically healthy, has good development and nutrition, and has normal organ function; 4.Laparoscopic surgery with a planned duration of = 2 hours (including but not limited to gastric cancer radical surgery, colorectal cancer radical surgery, renal cancer radical surgery, etc.); 5. Research participants or legal representatives sign a written informed consent form;
Exclusion criteria
Exclusion criteria: 1.Merge nasal anatomical abnormalities or active nasal diseases (such as nasal polyps, chronic rhinitis, etc.); 2. Previous diagnosis of neurological/psychiatric disorders or neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, epilepsy, etc.); 3. Uncontrolled severe cardiovascular disease (including but not limited to: systolic blood pressure = 180 mmHg and/or diastolic blood pressure = 110 mmHg, degree III or above atrioventricular block, sick sinus syndrome, symptomatic arrhythmia, etc.); 4.Moderate to severe damage to liver and kidney function (Child Pugh grade = B or eGFR4 weeks); 7.Allergic to butorphanol tartrate or contraindications to opioid use;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POCD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score (NRS score) and adverse reactions such as PONV;Surgical duration (record the total time from skin incision to incision closure) and anesthesia duration;Measurement of inflammatory markers: serum IL-1, IL-6, IL-10, TNF - a;MMSE score and MoCA score;Hemodynamics and BIS values; | — |
Countries
China
Contacts
Public ContactSun DeFeng
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed