postoperative delirium
Conditions
Interventions
Group P:Anesthesia induction using propofol at 1.5–2.0 mg/kg
Anesthesia maintenance using propofol at 4–12 mg/(kg·h) via target-controlled infusion with a microinfusion pump
Group C:Use ciprofol 0.3–0.4 mg/kg for induction of anesthesia.
Use ciprofol 0.8–2.4 mg/(kg·h) via microinfusion pump for target-controlled infusion to maintain anesthesia.
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the criteria for thoracoscopic surgery, consent to elective surgery, and are willing to undergo general anaesthesia; 2. Aged between 65 and 80 years, regardless of gender; 3. ASA Class I–III; 4. Body Mass Index (BMI) between 18 and 28 kg/m²; 5. No communication difficulties; 6. Frailty Screening Scale (FRAIL scale, FS) score >=3; 7. Able to complete the preoperative Mini-Mental State Examination (MMSE) with a score >= 26; 8. No significant abnormalities in cardiac, pulmonary, gastrointestinal, hepatic or renal function.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of cognitive impairment, dementia, delirium or cerebrovascular disease; 2. Patients suffering from severe depression, schizophrenia or other psychiatric or neurological disorders, or those who have previously taken antipsychotic or antidepressant medication; 3. Patients who have recently used probiotics, antibiotics, anti-inflammatory drugs, corticosteroids or other hormonal medications, or who have a recent history of tobacco or alcohol abuse or substance dependence; 4. Patients who are unable to complete the test due to severe visual, hearing or speech impairments; 5. Patients who are allergic to propofol or propofol cyclopentan;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium incidence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| severity of postoperative delirium;visual analogue scale; | — |
Countries
China
Contacts
Public ContactYali Ge
Northern Jiangsu People's Hospital
Outcome results
None listed