Postoperative Gastrointestinal Dysfunction
Conditions
Interventions
Intranasal dexmedetomidine combined with taVNS group (DT):Intranasal dexmedetomidine combined with taVNS
Intranasal dexmedetomidine combined with sham taVNS group (D):Intranasal dexmedetomidine combined with sham taVNS
taVNS combined with intranasal saline (T):taVNS combined with intranasal saline spray
Intranasal saline combined with sham taVNS (C):intranasal saline combined with sham taVNS
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.ASA?-?; 2.Elective laparoscopic gynecological surgery; 3. Age 18-65;
Exclusion criteria
Exclusion criteria: 1.Individuals with implanted electrical stimulation devices (such as pacemakers, etc.); 2.Individuals with airway hyperresponsiveness (e.g., asthma, COPD); 3.Individuals with an allergy to any of the medications used in this trial; 4.Individuals with hypotension, bradycardia, and sinus arrest; 5.Individuals with a history of allergic rhinitis ,nasal surgery or respiratory tract infections within the past 2 weeks; 6.Individuals with severe hepatic and renal dysfunction; 7.Individuals diagnosed with chronic gastrointestinal inflammation; 8.Individuals with a history of abdominal surgery or intestinal obstruction; 9.Individuals with long-term use of opioids; 10.Individuals unable to communicate normally;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea and vomiting;Intraoperative dosage of vasoactive drugs;Numerical rating scale score;Time to first postoperative defecation;Intraoperative opioid dosage;Incidence of intraoperative adverse reactions;Intake, Feeling nauseated, Emesis, Exam, and Duration of Symptoms Scoring System (I-FEED);Length of Stay (LOS); | — |
Countries
China
Contacts
Public ContactLinlin Zhao
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed