postoperative cognitive function
Conditions
Interventions
Observation group:None
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=65 years old, gender not restricted; 2. Clinically diagnosed with femoral neck fracture, hip joint osteoarthritis or femoral head necrosis, and scheduled for unilateral THA/HA; 3. Clear consciousness, and able to independently complete neuro-psychological assessment and questionnaire survey before the operation; 4. No contraindications for magnetic resonance imaging (such as absence of metal implants, no claustrophobia, etc.); 5. The patient and their family members voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: 1. There was a clear cognitive impairment before the surgery (MMSE score < 24, or MoCA score < 26); 2. There was a history of central nervous system diseases such as stroke, Parkinson's disease, Alzheimer's disease, etc. in the past; 3. History of mental disorders (such as schizophrenia, bipolar disorder) or long-term use of anti-psychotic drugs; 4. Severe liver and kidney dysfunction, malignant tumors, infectious diseases and other serious systemic complications; 5. Severe complications occurred after the surgery (such as periprosthetic infection, dislocation, massive bleeding, cerebral infarction, etc.), which affected the assessment or follow-up; 6. Unable to cooperate with the fMRI examination or lost contact during the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Pain degree;Sleep quality;Emotional State;The time of the first voluntary out-of-bed activity after the operation;Irritation of the drainage pipeline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain functional magnetic resonance imaging;General demographic data: age, gender, educational level, marital status, and mode of residence;Clinical data: Body mass index (BMI), comorbidities (hypertension, diabetes, coronary heart disease, etc., using Charlson comorbidities index score), surgical method (THA/HA), anesthesia method (spinal anesthesia/general anesthesia), operation duration, intraoperative blood loss, postoperative analgesia plan, indwelling time of drainage tube; | — |
Countries
China
Contacts
Public ContactLai Zhongmeng
Fujian Medical University Union Hospital
Outcome results
None listed