Cerebral Small Vessel Disease
Conditions
Interventions
Sponsors
Mianyang Central Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 50 and 80 years; 2.Able to cooperate with and complete the neuropsychological assessment; 3.Diagnosed with chronic cerebral small vessel disease (CSVD) according to the Standards for Reporting Vascular Changes on Neuroimaging 2 (STRIVE-2) [39] (2023). Clinical symptoms may include cognitive impairment, mood disorders, gait disturbances, and urinary/bowel dysfunction, or the patient may be asymptomatic; 4. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Intracranial or extracranial artery stenosis exceeding 50%, or a history of carotid endarterectomy; 2. White matter hyperintensities on imaging attributed to other diseases, such as multiple sclerosis or leukodystrophy; for this exclusion criterion, based on medical history and laboratory findings, white matter lesions caused by carbon monoxide poisoning, vasculitis, or hereditary CSVD (e.g., CADASIL) will also be excluded; 3. Concurrent hemorrhage or other pathological brain conditions, including central nervous system diseases such as traumatic brain injury, epilepsy, encephalitis, hydrocephalus, or brain tumors; 4. Movement disorders such as Parkinson's disease, or other somatic diseases that may lead to cognitive impairment; 5. Other systemic diseases (e.g., severe hepatic or renal dysfunction, malignancy, autoimmune diseases); 6. History of alcohol abuse or drug addiction, history of psychiatric disorders, or physical disabilities (including severe aphasia) that preclude cooperation; 7. Contraindications to MRI examination, including metallic implants such as cochlear implants, metal dental prostheses, cardiac pacemakers, or claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological Screening, including assessments of cognition, language, and emotion (50 minutes). Specific instruments include: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Animal Fluency Test, Digit Symbol Substitution Test, Trail Making Test, Hopkins Verbal Learning Test-Revised (HVLT-R), Rey-Osterrieth Complex Figure Test, Boston Naming Test (BNT), Clinical Dementia Rating (CDR), Neuropsychiatric Inventory Questionnaire (NPI-Q), Geriatric Depression Scale (G;Electroencephalography data;Functional near-infrared spectroscopy;Structural MRI data;functional MRI data; | — |
Countries
China
Contacts
Public ContactSu Muxiao
Mianyang Central Hospital
Outcome results
None listed