Complications within 30 days after the operation
Conditions
Interventions
Dexmedetomidine group:During the postoperative anesthesia recovery and mechanical ventilation in the AICU, dexmedetomidine was used for sedation.
Fospropofol disodium group:During the postoperative anesthesia recovery and mechanical ventilation in the AICU, fospropofol disodium was used for sedation.
Sponsors
The First People's Hospital of Foshan
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years; 2. ASA classification II~III; 3. Any of the following types of tertiary or higher-level laparoscopic or open surgeries: (1). Colorectal surgery;(2). Gynecological surgery;(3). Hepatobiliary pancreatic surgery;(4). Upper gastrointestinal surgery;(5). Urological surgery/kidney surgery. 4. Duration of surgery >= 2 hours; 5. Assess Respiratory Risk in Surgical Patients in Catalonia score indicating moderate-to-high risk. (ARISCAT score >= 26 points); 6. Postoperative requirement for transfer to the AICU for recovery with endotracheal intubation and mechanical ventilation, with an anticipated duration of mechanical ventilation exceeding 1 hour.
Exclusion criteria
Exclusion criteria: 1. BMI>=35 kg/m^2; 2. Pre-existing severe infection or sepsis; 3. Recent myocardial infarction (within the past 3 months), pre-existing heart failure with reduced ejection fraction (LVEF = 40%), or severe arrhythmias necessitating vasoactive drugs for hemodynamic stability; 4. Severe renal dysfunction (Chronic Kidney Disease, CKD stage 3 or higher); 5. Severe hepatic dysfunction (Child-Pugh class C); 6. Severe central nervous system diseases (e.g., Guillain-Barré syndrome), neuromuscular diseases (e.g., myasthenia gravis), or severe psychiatric disorders (e.g., schizophrenia); 7. Known allergy or contraindication to the study drugs; 8. Pregnancy or lactation; 9. Regular use of sedative-hypnotics or psychotropic drugs for more than one week; 10. Any other condition deemed by the investigator as unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of complications (Clavien-Dindo grade >=1) within 30 days after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Recovery-15 Score;The duration from the cessation of intravenous sedative drug infusion to the removal of the endotracheal tube;Total length of hospital stay;The percentage of the duration during which the target RASS score was maintained between -2 and 0, relative to the total duration of sedative drug infusion;Length of stay in the AICU; | — |
Countries
China
Contacts
Public ContactHanbing Wang
The First People's Hospital of Foshan
Outcome results
None listed