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Observational clinical study on the association between lactate-mediated gut microbiota alterations and disease progression in liver cirrhosis.

Observational clinical study on the association between lactate-mediated gut microbiota alterations and disease progression in liver cirrhosis.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600120746
Enrollment
Unknown
Registered
2026-03-19
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis

Interventions

Healthy control group:None

Sponsors

Zhujiang Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Healthy individuals without a history of liver disease or related underlying disorders; or patients diagnosed with liver cirrhosis and its complications based on imaging and/or liver biopsy, with a history of chronic liver disease for more than 6 months. Etiologies include chronic hepatitis B virus infection, nonalcoholic fatty liver disease, and alcoholic liver disease, among others. 2. Willing to participate in this study and able to provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. A history of severe organic diseases involving the liver, gastrointestinal tract, kidneys, or other organ systems; malignant tumors; or autoimmune diseases. 2. Patients with acute infection or inflammatory diseases within the past 1 month. 3. Pregnant or breastfeeding women.

Design outcomes

Primary

MeasureTime frame
Gut microbiota composition;Lactate level;

Countries

China

Contacts

Public ContactXiaolong He

Zhujiang Hospital of Southern Medical University

307660349@qq.com+86 186 2007 1640

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 3, 2026