Sepsis complicated by acute heart failure
Conditions
Interventions
Control group:Traditional Fluid Management
Intervention group:Dynamic Fluid Responsiveness Assessment-Guided Fluid Management
Sponsors
Emergency General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years; 2. Meet the diagnostic criteria for sepsis combined with acute heart failure; 3. Patient or their family has signed the informed consent form and is willing to participate in this study; 4. Expected hospital stay =48 hours to allow sufficient observation and intervention; 5. Patient is under mechanical ventilation and without arrhythmia, meeting the applicable conditions for non-invasive hemodynamic monitoring equipment.
Exclusion criteria
Exclusion criteria: 1.Have severe valvular heart disease (such as severe mitral or aortic stenosis) or other congenital heart diseases that may affect the implementation of hemodynamic monitoring and fluid management strategies; 2.Have severe liver and kidney failure (such as Child-Pugh Class C cirrhosis or end-stage renal disease), the complexity of which may interfere with the assessment of sepsis complicated by acute heart failure and the judgment of treatment efficacy. 3.Have an active malignancy with an expected survival time of less than 3 months, where the focus of treatment is more likely to be on palliative care rather than active interventions such as fluid resuscitation; 4.Presence of severe coagulation dysfunction (e.g., international normalized ratio [INR] > 3.0 or activated partial thromboplastin time [APTT] > 100 seconds), which may increase the risk of invasive procedures (such as central venous catheter insertion), thereby affecting the implementation of fluid management; 5.The patient or their legal guardians refuse to participate in this study or fail to comply with the various monitoring and intervention measures during the study process;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| APACHE II score;Hemodynamic parameters;Lactate clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; SOFA score; | — |
Countries
China
Contacts
Public ContactCui Juan
Emergency General Hospital
Outcome results
None listed