Scoliosis and Depression
Conditions
Interventions
Experimental group:Sufentanil + S-ketamine + dexmedetomidine
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
13 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1) Age >=13 years and =5 points; 3) Scheduled for elective scoliosis correction surgery (thoracolumbar fusion); 4) ASA (American Society of Anesthesiologists) physical status classification of I-III; 5) Use of patient-controlled intravenous analgesia (PCIA pump) postoperatively; 6) Consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1) Refusal to participate in this study; 2) Preoperative presence of sick sinus syndrome, severe sinus bradycardia (heart rate = III; 3) Patients with preoperative diagnosis of sleep apnea, or STOP-Bang score (Appendix 1) >= 3 and HCO3- >= 28 mmol/L; 4) Preoperative history of hyperthyroidism or pheochromocytoma; 5) Patients with preoperative schizophrenia, epilepsy, myasthenia gravis, or delirium; 6) Severe hepatic dysfunction (Child-Pugh Class C, Appendix 2); severe renal dysfunction requiring preoperative dialysis; ASA physical status >= IV; 7) Inability to comprehend visual analog scales or presence of language communication barriers; 8) Other conditions deemed unsuitable for study participation by the investigator or attending physician; 9) Preoperative use of ketamine or allergy to ketamine/S-ketamine; 10) Cases requiring high-grade osteotomy (e.g., VCR osteotomy); 11) Current participation in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of chronic pain at 3 months post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe pain within 72 hours postoperatively;Resting and activity-related pain NRS scores at various time points within 3 days postoperatively;;Total opioid consumption within 3 days postoperatively;Cumulative consumption of analgesic drugs within 3 days postoperatively;RASS scores at various time points within 3 days postoperatively;Sleep NRS scores at 3 nights post-surgery, 30 days, and 90 days;Postoperative Hospital Stay;PHQ-9 Depression Score at 7 days, 30 days, and 90 days post-surgery;Total analgesic administration time within 30 days postoperatively;Incidence of complications (including all-cause mortality) within 30 days postoperatively; | — |
Countries
China
Contacts
Public ContactJinhua Bo
Nanjing Drum Tower Hospital
Outcome results
None listed