Knee replacement surgery
Conditions
Interventions
Control Group:8ml of 0.375% bupivacaine (20mg) for proximal femoral triangle block
postoperative PCA pump (morphine 50mg + normal saline 100ml)
Trial Group:4ml conventional bupivacaine (20mg) + 4ml liposomal bupivacaine for femoral triangle block (small-volume regimen)
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective knee arthroplasty under general anesthesia; 2. American Society of Anesthesiologists (ASA) physical status I–III, aged 19 to 80 years; 3. No cognitive, communication disorders, or mental abnormalities; able to communicate, comprehend, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Rheumatoid arthritis; 2. Allergy to the study drugs (ropivacaine, liposomal bupivacaine) or contraindications to peripheral nerve blocks (local or systemic infection; pre-existing neurological deficits or neuropathy); 3. Moderate or severe liver dysfunction (AST or ALT > 2.5 times the upper limit of normal); serum total bilirubin (TBIL) > 3 times the upper limit of normal, serum albumin 1.5; 4. Estimated glomerular filtration rate 265 µmol/L (male) or > 221 µmol/L (female), blood urea nitrogen (BUN) > 21.4 mmol/L, urinalysis showing massive proteinuria or hematuria; 5. Chronic opioid use (>= 4 weeks preoperatively, with a daily morphine equivalent dose >= 30 mg); 6. Unstable psychiatric disorders; 7. Inability to communicate with the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour morphine consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numerical Rating Scale (NRS) score (resting and activity-related pain);Incidence of breakthrough pain;Postoperative mobility function on days 1–3;Patient satisfaction;Postoperative recovery index;Maximum voluntary motor contraction force before and 15 minutes after blockade;Sensory assessment before and 15 minutes after blockade;Opioid-related adverse events;Blockade-related adverse events;Systemic complications; | — |
Countries
China
Contacts
Public ContactQuanguang Wang
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed