Parkinson's disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosed with primary Parkinson's disease according to the clinical diagnostic criteria for Parkinson's disease issued by the International Parkinson and Movement Disorder Society in 2015; 2. Age between 40–80 years; 3. Patients complain of difficulty initiating movement or experiencing freezing episodes (UPDRS item 14 score >=1); 4. Diagnosed as H-Y stage 1–3; 5. Normal hearing, no severe cognitive impairment, Mini-Mental State Examination (MMSE) total score >=21; 6. No comorbid psychiatric disorders or severe anxiety, Hamilton Anxiety Scale total score <21, and able to cooperate with MRI scanning; 7. Willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Any primary orthopedic, neurological, or visual disorders other than Parkinson's disease that may cause gait disturbances; 2. Individuals with a clear history of neurological diseases; 3. Presence of contraindications to MRI scans, such as metal implants or claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Simple Balance Test; | — |
Secondary
| Measure | Time frame |
|---|---|
| New Freezing of Gait Questionnaire;Parkinson's Disease Questionnaire - 39 Items; | — |
Countries
China
Contacts
Qilu Hospital of Shandong University(Qingdao)