Allergic Rhinitis
Conditions
Interventions
Drug Treatment Group:Loratadine + Intranasal Corticosteroids
Dust Mite Single ILIT Group:Intralymphatic injection of dust mite allergen 1000SQ into inguinal lymph node, 0.1ml
Animal Dander Single ILIT Group:Intralymphatic injection of animal dander allergen 1:100000 (dilution factor) into inguinal lymph node, 0.1ml
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All the research subjects met the diagnostic criteria for allergic rhinitis. 2. The allergic allergens of all the research subjects were dust mites and animals (positive skin prick test or allergen-specific lgE serum level greater than or equal to 0.35kU/L).
Exclusion criteria
Exclusion criteria: 1. Uncontrolled or severe asthma (FEV1<70%) 2. Accompanied by psychological and mental disorders, unable to cooperate with treatment 3. Accompanied by severe immune, congenital, cardiovascular and cerebrovascular diseases. 4. Has experienced serious adverse reactions of AIT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite Symptom and Medication Score (CSMS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ);Nasal Provocation Test Results;Immunological Parameters (Specific Antibodies and Nasal Cytology); | — |
Countries
China
Contacts
Public ContactKe Xia
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed