Thalassemia
Conditions
Interventions
Normal Control Group:None
Alpha Thalassemia Gene Carrier Group:None
Beta Thalassemia Gene Carrier Group:None
Non-Transfusion Dependent Thalassemia Group:None
Transfusion Dependent Thalassemia Group:None
Sponsors
The Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 30 Years
Inclusion criteria
Inclusion criteria: 1.Refinement of thalassemia gene mutation assays for definitive diagnosis in patients aged 0-30 years. 2.No underlying conditions were identified in other organ systems apart from thalassemia. 3.Patients who are informed and consent to participate in this study. 4.The control group consisted of healthy individuals without underlying conditions such as thalassemia, malignancies, infections, or lipid metabolism disorders.
Exclusion criteria
Exclusion criteria: 1.Presence of comorbidities other than thalassemia and its complications, such as infections, malignancies, inherited metabolic disorders, and autoimmune diseases; 2.Coexistence of other conditions that cause anemia apart from thalassemia; 3.History of blood transfusion within the past three months; 4.Patients or their legal guardians who decline to participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demographic and anthropometric data (sex, age, height, weight);Clinical manifestations (anemia symptoms, jaundice, hepatosplenomegaly, skeletal changes, growth and development status, comorbidities);Laboratory and imaging assessments (thalassemia gene mutation detection, hemoglobin level, MCV, MCH, MCHC, RDW, absolute reticulocyte count, serum ferritin, red blood cell osmotic fragility test, liver and cardiac T2* MRI, liver and spleen ultrasound);Treatment regimen (no treatment, oral chelation therapy use, number of transfusions, etc.);Lipid metabolomics profiling data; | — |
Countries
China
Contacts
Public ContactZhu Chunjian
The Affiliated Hospital of Guilin Medical University
Outcome results
None listed