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A Predictive Nomogram for Hemorrhagic Transformation Risk Following Perioperative Tirofiban in Acute Ischemic Stroke.

A Predictive Nomogram for Hemorrhagic Transformation Risk Following Perioperative Tirofiban in Acute Ischemic Stroke.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600120685
Enrollment
Unknown
Registered
2026-03-18
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke

Interventions

Non-Hemorrhagic group:None
Hemorrhagic group:None

Sponsors

Army Medical Center of PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.age>=18 years; 2.Preoperative computed tomographic angiography (CTA) or magnetic resonance angiography (MRA) indicating large vessel occlusion (LVO) in the anterior circulation. 3.Endovascular treatment (EVT) performed within 24 hours of onset, or within 48 hours for patients with a significant ischemic penumbra identified by CT perfusion (CTP), supplemented with perioperative tirofiban as adjunctive therapy; 4.Stroke etiology classified as Large-Artery Atherosclerosis (LAA) according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria.

Exclusion criteria

Exclusion criteria: 1.Pre-stroke modified Rankin Scale (mRS) score > 2; 2.History of intracranial hemorrhage or admission imaging showing evidence of intracranial bleeding; 3.Concurrent intracranial aneurysm or arteriovenous malformation; 4.Missing or incomplete key baseline data.

Design outcomes

Primary

MeasureTime frame
Intracranial hemorrhage;

Secondary

MeasureTime frame
90-day mortality;Symptomatic intracranial hemorrhage;90-day mRS scores;

Countries

China

Contacts

Public ContactZhang Meng

Army Medical Center of PLA

zhangmeng861@qq.com+86 23 68757816

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 3, 2026