postoperative delirium
Conditions
Interventions
L Group:Bolus dose: Within 10 minutes before anesthesia induction, 1% lidocaine hydrochloride injection (5 ml:0.1 g, CSPC Yinhu Pharmaceutical Co., Ltd., National Drug Approval Number H14024045) was s
the infusion rate was set in ml/h based on body weight to ensure accurate dosing.
C Group:Bolus dose: An equal volume of 0.9% normal saline was administered intravenously at the same time point.
Maintenance dose: An equal volume and rate of 0.9% normal saline was infused continuous
Sponsors
Mianyang Central Hospital
Eligibility
Sex/Gender
Female
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: Indicated for laparoscopic hysterectomy;Age = 60 years;Body mass index (BMI) 17–27 kg/m²;American Society of Anesthesiologists (ASA) physical status classification ?–?;No hepatic or renal dysfunction;Informed consent obtained and voluntarily signed before participation.
Exclusion criteria
Exclusion criteria: Allergy to lidocaine;History of severe neurological or psychiatric disorders;History of drug abuse;Severe cardiopulmonary disease;Cerebrovascular disease;Preoperative Mini-Mental State Examination (MMSE) score below normal range (illiterate <17, primary school <20, middle school or above <24);Blindness, previous ophthalmic surgery, or history of ocular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative incidence of POD within 7 days postoperatively. ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameter;mean arterial pressure;heart rate; | — |
Countries
China
Contacts
Public ContactWeng Man
Mianyang Central Hospital
Outcome results
None listed