Refractory Parathyroid Carcinoma
Conditions
Interventions
Experimental Group:Temozolomide
Sponsors
Chinese Academy of Medical Sciences, Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients with parathyroid carcinoma jointly assessed by the teams from the Department of Endocrinology and the Department of General Surgery, Peking Union Medical College Hospital, as being unsuitable for repeat surgery, or those who explicitly refuse surgical treatment; 2.At least one month since the last treatment (e.g., surgery), with documented non-response (disease not in remission); 3.Age > 18 years and = 3 × 10^9/L, NEUT >= 1.5 × 10^9/L, PLT >= 100 × 10^9/L, HGB >= 85 g/L), and normal cardiac and pulmonary function;^95.Patients of childbearing potential agree to use contraception; 6.Patients provide written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1.Presence of other malignant tumors, excluding carcinoma in situ and basal cell carcinoma; 2.Currently receiving other anti-tumor drug therapy; 3.Pregnant or breastfeeding women; 4.History of allergy to temozolomide, dacarbazine, or related drugs; 5.Severe bone marrow suppression; 6.Severe hepatic or renal insufficiency; 7.Presence of the following cardiovascular conditions: 1) QTc prolongation or other clinically significant ECG abnormalities; 2) Current or prior cardiac insufficiency, NYHA Class III or IV; 3) Myocardial infarction, arrhythmias other than sinus tachycardia, stable or unstable angina, symptomatic congestive heart failure, or coronary/peripheral artery bypass graft surgery or stent implantation within the past 12 months; 8.Intestinal obstruction or other conditions affecting drug administration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease Control Rate (DCR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival (PFS);Biochemical remission rate; | — |
Countries
China
Contacts
Public ContactSong An
Chinese Academy of Medical Sciences, Peking Union Medical College Hospital
Outcome results
None listed