Ischemic Stroke
Conditions
Interventions
Ischaemic stroke group:None
Health Group:None
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Acute Ischemic Stroke Patient Group (80 cases) 1. Age 18-90 years; 2. Time from onset to enrollment >= 24 hours (excluding wake-up strokes); 3. Definite diagnosis of acute ischemic stroke based on clinical presentation and head CT or MR imaging; 4. Pre-treatment NIHSS score 6 >= score >= 25; 5. Meeting one of the following conditions: Not receiving reperfusion therapy (20 cases); Thrombolysis therapy (20 cases): receiving intravenous thrombolysis within 24 hours of symptom onset; Endovascular intervention therapy (20 cases): able to undergo endovascular intervention (including intra-arterial thrombolysis, mechanical thrombectomy, stent retriever) within 24 hours of stroke onset; Bridging therapy (20 cases): able to undergo bridging therapy (i.e., intravenous thrombolysis followed by endovascular intervention) within 24 hours of stroke onset; 6. Patients and their families are fully informed about the trial process and voluntarily sign the informed consent form. Healthy Control Group (20 cases) 1. Age 18-90 years; 2. No previous medical history, including but not limited to neurological diseases (such as stroke, headache, cognitive impairment), cardiovascular diseases, metabolic diseases, etc.; 3. No history of any medication, especially those affecting the immune system or steroid therapy; 4. Fully understand the trial process and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Acute Ischemic Stroke Patient Group (80 cases) 1. Neurological diseases: Diagnosed with other cerebrovascular diseases (e.g., cerebral hemorrhage, cerebral venous sinus thrombosis); Diagnosed with non-cerebrovascular diseases (e.g., central nervous system infection, seizure disorder, metabolic encephalopathy); History of traumatic brain injury or brain surgery; 2. Other systemic diseases: Malignancy in other regions; Severe liver or kidney dysfunction or cardiac failure; Persistent infection; Coagulation disorders or hematological diseases; Autoimmune diseases; HIV (immunocompromised state); Myocardial infarction within the last 3 months; 3. Concurrent use of steroids or immunotherapy; 4. Life expectancy less than 3 months or inability to complete study follow-up for other reasons; 5. Concurrent participation in other clinical trials. Healthy Control Group (20 cases) 1. Concurrent participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of Receptor-Interacting Protein Kinase 1 (RIPK1) in Peripheral Blood;Level of Phosphorylated Receptor-Interacting Protein Kinase 1 (P-RIPK1) in Peripheral Blood;Level of Receptor-Interacting Protein Kinase 3 (RIPK3) in Peripheral Blood;Level of Phosphorylated Receptor-Interacting Protein Kinase 3 (P-RIPK3) in Peripheral Blood;Level of Mixed Lineage Kinase Domain-Like Protein (MLKL) in Peripheral Blood;Level of Phosphorylated Mixed Lineage Kinase Domain-Like Protein (P-MLKL) in Peripheral Blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of Neuronal Injury Marker Neurofilament Light Chain (NfL) in Peripheral Blood;Level of Immune-Inflammatory Regulatory Factor Tumor Necrosis Factor-a (TNF-a) in Peripheral Blood;Level of Immune-Inflammatory Regulatory Factor Interleukin-1ß (IL-1ß) in Peripheral Blood;Level of Immune-Inflammatory Regulatory Factor Interleukin-6 (IL-6) in Peripheral Blood;Level of Immune-Inflammatory Regulatory Factor Interleukin-16 (IL-16) in Peripheral Blood;Level of Immune-Inflammatory Regulatory Factor Interleukin-19 (IL-19) in Peripheral Blood;Level of Immune-Inflammatory Regulatory Factor C-C Motif Chemokine Ligand 17 (CCL17) in Peripheral Blood;National Institutes of Health Stroke Scale (NIHSS) Score;Modified Rankin Scale (mRS) Score; | — |
Countries
China
Contacts
Public ContactZixiao Li
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed