Patients at high hypoxaemia risk
Conditions
Interventions
Group N:Nasal cannula oxygen therapy
Group B:Bilevel Positive Airway Pressure
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Undergoing painless gastrointestinal endoscopy; 3. Individuals at risk of hypoxaemia, meeting any one of the following criteria: (1) Age > 60 years; (2) Frailty (Frail Scale score >= 3); (3) American Society of Anesthesiologists (ASA) physical status III–IV; (4) Obesity (BMI >= 30 kg/m²); (5) Sleep apnoea or STOP-Bang score >= 3; (6) Coexisting cardiac disease (left ventricular dysfunction with left ventricular ejection fraction <= 45%, ischaemic heart disease, chronic atrial fibrillation, cardiogenic pulmonary oedema, hypertension); (7) Coexisting respiratory disease (COPD, emphysema, bronchiectasis, asthma, pleural effusion, pulmonary interstitial fibrosis).
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will be excluded from the study: 1. Patients with a tracheostomy; 2. Pneumothorax, mediastinal emphysema; cerebrospinal fluid leakage, craniocerebral trauma, or intracranial pneumatosis; 3. Active epistaxis or uncontrolled upper gastrointestinal bleeding; 4. Hepatic or renal dysfunction; 5. Massive vocal cord polyps, acute pharyngitis, tonsillitis, or acute exacerbation of asthma; 6. Patient non-compliance or known allergy to propofol or any component of its emulsion; 7. Participation in another clinical study within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypoxaemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of hypoxaemic episodes;Time from completion of induction (MOAA/S = 1) to SpO? < 75%;Duration of hypoxaemia;Time from completion of induction (MOAA/S = 1) to SpO? < 90%; | — |
Countries
China
Contacts
Public ContactNa Xing
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed