colorectal adenocarcinoma (including mucinous adenocarcinoma/signet-ring cell carcinoma)
Conditions
Interventions
neo-adjuvant queue:[68Ga]Ga-NNFBP4 PET/CT
Imaging feature queue:[68Ga]Ga-NNFBP4 PET/CT
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75, with no gender restrictions; 2. Pathologically confirmed colorectal adenocarcinoma (including mucinous adenocarcinoma/signet-ring cell carcinoma); 3. Suspected recurrence/metastasis after surgery or treatment (suspicious imaging findings or elevated blood tumor markers); 4. Prior to any evaluation, the subject or their legal guardian must understand and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Suffering from cardiovascular, liver, kidney, blood system, tumor, endocrine, respiratory system, immune deficiency, or other severe diseases. (1) Cardiovascular system diseases: NYHA class III–IV heart failure; acute coronary syndrome or severe arrhythmia within the past 6 months; systolic blood pressure =180 mmHg or diastolic blood pressure =110 mmHg and uncontrolled; (2) Liver function abnormalities: Child–Pugh class C liver insufficiency; ALT or AST =3 times the upper limit of normal, or total bilirubin =2 times the upper limit of normal; (3) Kidney function abnormalities: eGFR <30 mL/min/1.73m²; requiring dialysis; (4) Hematologic diseases: neutrophils <1.5×10?/L; platelets <75×10?/L; active bleeding or severe coagulation dysfunction; (5) Malignant tumors: history of malignant tumors other than the study-related tumor within the past 5 years; (6) Respiratory system diseases: severe or very severe chronic obstructive pulmonary disease (GOLD III–IV); (7) Immune system diseases or immunodeficiency status requiring long-term systemic immunosuppressive therapy; (8) Other severe diseases that, in the investigator's assessment, may significantly affect study safety or the reliability of results. 2. Suffering from claustrophobia. 3. History of drug abuse or alcoholism. 4. Pregnant or lactating women. 5. Having any condition that the study sponsor believes may pose a risk or potential harm in any aspect related to this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor uptake level (expressed as SUV value); | — |
Countries
China
Contacts
Public ContactHuo Li, Zhang Xianzhong
Peking Union Medical College Hospital
Outcome results
None listed