Normal-tension glaucoma
Conditions
Interventions
The first stage is the self-control group:All enrolled NTG patients received 28-day RLRL treatment while maintaining their original intraocular pressure control regimens. Eyes with more severe visual
The second stage is the self-control group:Based on the data from the first stage of the research, it will be decided whether to conduct the second stage of the research (including the remaining 20 su
Sponsors
Shenzhen Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 50 years; 2. Previously diagnosed with normal-tension glaucoma based on the following criteria: (1) Previously untreated intraocular pressure, 24-hour IOP fluctuation, and peak IOP were all 0.5; 2) Asymmetric cup-to-disc ratio, C/D difference > 0.2; 3) Optic disc hemorrhage; 4) Neuroretinal rim notching or retinal nerve fiber layer thinning corresponding to visual field defect; (3) Open angles in both eyes on gonioscopy; (4) Typical glaucomatous visual field defect (Humphrey Field Analyzer), defined as one or more of the following: 1) Mean Deviation and Pattern Standard Deviation outside 95% confidence interval; 2) Glaucoma Hemifield Test results outside normal limits; 3) At least three points with P = 0.7.
Exclusion criteria
Exclusion criteria: 1. Spherical equivalent refractive error in both eyes > +3.00 D or 20%, false positives > 15%, or false negatives > 33%; 7. Visual afterimages lasting longer than 5 minutes following red light exposure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in peripapillary vessel density after 28 days of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in peripapillary retinal nerve fiber layer thickness after 28 days of treatment;Changes in uncorrected visual acuity and best-corrected visual acuity after 28 days of treatment;Changes in refractive error after 28 days of treatment;Changes in axial length after 28 days of treatment;Changes in macular vascular density after 28 days of treatment;Changes in intraocular pressure and ocular perfusion pressure after 28 days of treatment;Changes in choroidal thickness and choroidal vascular index after 28 days of treatment;Adverse Events; | — |
Countries
China
Contacts
Public ContactFan Ning
Shenzhen Eye Hospital
Outcome results
None listed