None
Conditions
Interventions
OPA group:Conventional opioid-based anesthesia
SPI-OFA group:Surgical Pleth Index (SPI)-guided opioid-free anesthesia
Sponsors
Ningbo Medical Centre Lihuili Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 75 years. ,ASA physical status I or II; 2.Scheduled for an elective laparoscopic general surgical procedure (e.g., cholecystectomy, appendectomy, inguinal hernia repair); 3.Provided voluntary written informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe dysfunction of the heart, lungs, liver, or kidneys; 2.History of chronic pain or long-term use of opioids/sedatives; 3.Known allergy or contraindication to any study medication (e.g., propofol, remifentanil, dexmedetomidine, lidocaine, esketamine, NSAIDs); 4.Severe arrhythmia or peripheral vascular disease potentially affecting SPI signal quality; 5.Psychiatric or cognitive impairment preventing cooperation with postoperative assessments; 6.Pregnancy or lactation; 7.Body mass index (BMI) > 35 kg/m^2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting, respiratory depression, and pruritus;Frequency of intraoperative rescue interventions;QoR-15 score at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative tramadol consumption;Dosage of opioids (sufentanil, remifentanil) and esketamine, along with the number of administrations and dosage of vasoactive drugs;Protocol deviation rate;Postoperative pain NRS score;Mean Arterial Pressure,Heart Rate and Surgical Pleth Index; | — |
Countries
China
Contacts
Public ContactZhang Ying
Ningbo Medical Centre Lihuili Hospital
Outcome results
None listed