Schizophrenia
Conditions
Interventions
Treatment group:Olanzapine combined with Tetralogy of viable bifidobacterium
Sponsors
JiangXi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients with schizophrenia who were hospitalized at the Jiangxi Mental Health Center from January 2026 to December 2026 and met the inclusion criteria were selected. 1. Conform to the diagnostic criteria of schizophrenia in ICD-10; 2.Age between 18 and 60 years old; 3.Have taken olanzapine for 4 weeks; 4.Can follow the treatment plan and undergo relevant examinations during the study period; 5.Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with severe physical diseases or other mental disorders; 2. Fasting blood glucose > 7.0 mmol/L, blood glucose 2 hours after meal > 11.1 mmol/L; 3. Low-density lipoprotein cholesterol (LDL-C) > 4.9 mmol/L; 4. Patients with a recent recurrence of schizophrenia who do not cooperate with treatment or examinations; 5. Pregnant or lactating women; 6. Allergic to olanzapine or the components of bifidobacterium quadruple live bacteria tablets; 7. Patients using other antipsychotic drugs or probiotic preparations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The concentrations of GLU, TG, TC, HDL-C, and LDL-C in serum;The concentrations of IL-6, TNF - a, IL-22 and IGF2 in plasma; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment Emergent Symptom Scale score;Positive and Negative Syndrome Scale score; | — |
Countries
China
Contacts
Public ContactLuo Cuiping
JiangXi Mental Health Center
Outcome results
None listed