Parkinson's Disease
Conditions
Interventions
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for PD group: (1) All PD patients were independently diagnosed as clinically confirmed or clinically probable PD patients by 2 or more professional neurologists according to the MDS diagnostic criteria in 2015; (2) Male or female, aged 45 - 75 years; (3) Educational background was not limited, MoCA>20 points; (4) Understanding and signing informed consent form; 2. Inclusion criteria of healthy control group: (1) Age, gender, years of education matched with PD group and MoCA=26 points; (2) No complaint of memory impairment; (3) Ability to complete neuropsychological assessment tests; (4) Understanding and signing informed consent forms;
Exclusion criteria
Exclusion criteria: 1. History of serious diseases affecting brain function: such as Fazakes grade =II white matter hyperintensity, Hachinski score>4, brain trauma, history of brain surgery, encephalitis, epilepsy, etc.; 2. History of serious diseases, such as mental and psychological diseases (e.g. schizophrenia, HAMA>29 points, HAMD-17>24 points), cancer, hyperthyroidism, alcoholism, carbon monoxide poisoning, drug abuse and systemic diseases; 3. Vision and hearing abnormalities, severe aphasia or paralysis and inability to cooperate due to motor symptoms; 4. Taking anticholinergic drugs (e.g. benzhydryl).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in PD Cognitive Domain Assessment Scale Score from Baseline to 1 Year Follow-up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Cognitive-Related Biomarkers (T-tau, p-tau-181, Aß-40, Aß-42, NFL, a-synuclein) from Baseline to Follow-up; | — |
Countries
China
Contacts
Public ContactXu Erhe
Xuanwu Hospital, Capital Medical University
Outcome results
None listed