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Analysis of efficacy and safety of Intravenous thrombolysis in acute cerebral infarction guided by modified DWI-quantified FLAIR mismatch beyond the time window

Analysis of efficacy and safety of Intravenous thrombolysis in acute cerebral infarction guided by modified DWI-quantified FLAIR mismatch beyond the time window

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600120586
Enrollment
Unknown
Registered
2026-03-17
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute cerebral infarction

Interventions

Complete flair mismatch group:None
Partially mismatched group:None

Sponsors

Wuhan Fourth Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Diagnosis of acute cerebral infarction meeting the stroke diagnostic criteria outlined in the 2018 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke established by the Cerebrovascular Disease Group of the Neurology Branch of the Chinese Medical Association; 2.Time from last normal appearance to hospital admission between 4.5 and 24 hours; 3.NIHSS score >= 4; 4.Age between 18 and 80 years; 5.Pre-onset modified Rankin Scale (mRS) score of 0–1;

Exclusion criteria

Exclusion criteria: 1.Patients unable to undergo cranial multimodal MRI examination or with poor image quality rendering analysis impossible; 2.Patients with unstable vital signs; 3.Patients confirmed via CT or MRI at admission to have cerebral infarction complicated by hemorrhage or tumor; 4.Severe stroke (NIHSS score > 25); 5.Patients with severe cardiac, hepatic, renal, or pulmonary dysfunction, or coagulation disorders; 6.Patients undergoing endovascular intervention.

Design outcomes

Primary

MeasureTime frame
Baseline data, NIHSS scores;

Secondary

MeasureTime frame
Rates of incidence rates of intracranial hemorrhage?death and severe disability;Favorable outcome rates (MRS modified Rankin Scale 0-1);

Countries

China

Contacts

Public ContactXifeng Wang

Wuhan Fourth Hospital

1183148404@qq.com+86 27 83930106

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 3, 2026