Mental Disorders
Conditions
Interventions
Case group:None
Control group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with mental disorders in high-altitude areas: (1) Age between 18 and 55 years old, with no gender restrictions; (2) Right-handed; (3) Long-term residence in high-altitude areas (altitude >= 2500 meters); (4) Meeting the diagnostic criteria for mental disorders as per DSM-5. Inclusion criteria for healthy controls in high-altitude areas: (1) Gender, age, years of education, and living conditions in the high-altitude area (altitude = 2500 meters) are matched with the patients with mental disorders group; (2) Right-handed. Inclusion criteria for patients with mental disorders in low-altitude areas: (1) Age between 18 and 55 years old, with no gender restrictions; (2) Right-handed; (3) Long-term residence in low-altitude areas (altitude <=1500 meters); (4) Meeting the diagnostic criteria for mental disorders as per DSM-5. Inclusion criteria for healthy controls in low-altitude areas: (1) Gender, age, years of education, and living conditions in the low-altitude area (altitude = 1500 meters) are matched with the patients with mental disorders group; (2) Right-handed.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with mental disorders in high-altitude areas: (1) Have major physical diseases such as altitude sickness, severe cardiovascular diseases, liver and kidney diseases, etc.; (2) Have a history of brain trauma or have been in a coma for more than 10 minutes; (3) Have metal implants in the body or have claustrophobia, which are contraindications for MRI scans. Exclusion criteria for healthy controls in high-altitude areas: (1) Have major physical diseases such as altitude sickness, severe cardiovascular diseases, liver and kidney diseases, etc.; (2) Have a history of mental disorders and family history; (3) Have a history of brain trauma or have been in a coma for more than 10 minutes; (4) Have metal implants in the body or have claustrophobia, which are contraindications for MRI scans. Exclusion criteria for patients with mental disorders in low-altitude areas: (1) Have severe cardiovascular, liver and kidney diseases, etc. as major physical diseases; (2) Have a history of brain trauma or have been in a coma for more than 10 minutes; (3) Have metal implants in the body or have claustrophobia, which are contraindications for MRI scans. Exclusion criteria for healthy controls in low-altitude areas: (1) Have severe cardiovascular, liver and kidney diseases, etc. as major physical diseases; (2) Have a history of mental disorders and family history; (3) Have a history of brain trauma or have been in a coma for more than 10 minutes; (4) Have metal implants in the body or have claustrophobia, which are contraindications for MRI scans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain structure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mental disorder;Anxiety;Somatic symptoms; | — |
Countries
China
Contacts
Public ContactXu Jiajun
West China Hospital, Sichuan University
Outcome results
None listed