Acute pancreatitis
Conditions
Interventions
Control group:Conventional therapy (fasting, gastrointestinal decompression, fluid resuscitation, inhibition of gastric and pancreatic secretion, suppression of pan
Ursodeoxycholic acid (Ursofalk) group:Ursodeoxycholic acid (Ursofalk)
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for acute pancreatitis; 2.Aged between 18 and 75 years; 3.Onset within 72 hours; 4.Modified Harmless Acute Pancreatitis Score >= 3 or SIRS >= 2; 5.Signed informed consent form;
Exclusion criteria
Exclusion criteria: 1.SAP patients with organ failure at admission (Marshall score >=2); 2.Known hypersensitivity to ursodeoxycholic acid; 3.Imaging evidence (ultrasound, CT, etc.) of biliary obstruction, including common bile-duct stones or pancreaticobiliary tumours; 4.Severe hepatic dysfunction (ALT or AST > 3 × ULN, or total bilirubin > 2 × ULN); 5.Severe impairment of vital organs (heart, lung, kidney, etc.); 6.Pregnant or lactating women; 7.Participation in another clinical trial; 8.Any condition that, in the investigator’s opinion, would expose the subject to unacceptable risk of complications, interfere with the evaluation of the investigational product, or confound the interpretation of safety or efficacy data; 9.Failure to provide informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of new-onset SIRS within 7 days or duration of persistent SIRS.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal function recovery;Laboratory parameters;Infection-related indicators; | — |
Countries
China
Contacts
Public ContactXiong Huifang
The first affiliated hostipal of nanchang university
Outcome results
None listed