Premature Ventricular Contraction
Conditions
Interventions
Healthy control group:None
Wide QRS Premature Ventricular Contractions:None
Narrow QRS Ventricular Premature Contractions Group:None
Sponsors
Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age over 65 years; 2. Idiopathic Premature Ventricular Contractions (PVCs): High PVC burden demonstrated by 24-hour ambulatory electrocardiography (Holter) within the past month, with no identifiable etiology after comprehensive evaluation; 3. Normal Left Ventricular Function: Left ventricular ejection fraction (LVEF) measured by Simpson’s method on echocardiography within the past month =50%; 4. Asymptomatic or minimally symptomatic, with no prior treatment using Class I/III antiarrhythmic drugs (AADs) or radiofrequency ablation; 5. Duration of Premature Ventricular Contractions exceeding 1 year.
Exclusion criteria
Exclusion criteria: 1. Transthoracic echocardiography indicating left ventricular ejection fraction (LVEF) =50% and NT-proBNP>125 pg/mL), consistent with the recommendations of the "2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure". 3. Patients with arrhythmias other than premature ventricular contractions and short runs of ventricular tachycardia (such as atrial fibrillation, atrial flutter, frequent premature atrial contractions, conduction system diseases, etc.). 4. Currently using Class I/III antiarrhythmic drugs (AAD) or undergoing ablation therapy. 5. Other known diseases affecting left ventricular function, including hypertension, coronary artery disease, valvular heart disease, congenital heart disease, pulmonary heart disease, thyroid disease, severe hepatic or renal insufficiency, and other conditions affecting left ventricular function. 6. Patients with poor echocardiographic image quality that does not meet image analysis requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left Ventricular Global Work Efficiency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Global Work Index;Effective Work;Non-Effective Work;Conventional Echocardiographic Parameters; | — |
Countries
China
Contacts
Public ContactWen Heling
Sichuan Provincial People's Hospital
Outcome results
None listed