CRAB infection after solid organ transplantation
Conditions
Interventions
Observation group:None
Sponsors
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 and =8 µg/mL, according to CLSI 2024 criteria); 4. Received durlobactam/sulbactam therapy for >=72 hours (patients who discontinued treatment or died due to clinical deterioration within 72 hours should have the specific reasons documented, included in safety analysis but excluded from efficacy analysis); 5. Complete clinical data available (including transplant type, post-transplant immunosuppressive regimen, infection site, CRAB susceptibility results, durlobactam/sulbactam dosage and treatment duration, efficacy evaluation indicators, laboratory test results, adverse reaction records, etc.).
Exclusion criteria
Exclusion criteria: 1. Treatment duration of durlobactam/sulbactam =50% of key efficacy indicators, medication dosage or adverse reaction records); 3. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical cure rate;Microbial clearance rate;All-cause survival rate at 30 days;All-cause survival rate at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to infection control;Total duration of antimicrobial therapy;Recurrence rate of CRAB infection during follow-up; | — |
Countries
China
Contacts
Public ContactQian Yongbing
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed