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Mechanism of C3b/VSIG4 signaling inhibiting macrophage STING-mediated necrotizing apoptosis in attenuating ischemia-reperfusion liver injury

Mechanism of C3b/VSIG4 signaling inhibiting macrophage STING-mediated necrotizing apoptosis in attenuating ischemia-reperfusion liver injury

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600120455
Enrollment
Unknown
Registered
2026-03-16
Start date
2024-10-25
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver ischemia-reperfusion injury

Interventions

Observation group:None
Control group:None
Acute liver injury group:None

Sponsors

Tongji Hospital of Tongji University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Experimental group: patients diagnosed with acute liver injury or patients with ischemia-reperfusion liver injury caused by liver surgery; 2.Control group: Except for patients with acute liver injury and ischemia-reperfusion liver injury due to liver surgery; 3.Voluntarily sign informed consent; 4.Patients between the ages of 18 and 80;

Exclusion criteria

Exclusion criteria: 1.Patients with chronic liver injury; 2.Pregnant and lactating women, bipolar disorder, schizophrenia and other serious mental disorders; 3.Patients younger than 18 years or older than 80 years;

Design outcomes

Primary

MeasureTime frame
Protein marker;—

Countries

China

Contacts

Public ContactWeifeng Tan

Tongji Hospital of Tongji University

20537@renji.com+86 18918811855

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 3, 2026