Post-hemorrhoidectomy Pain
Conditions
Interventions
Pudendal nerve block group (normal saline group, NA group):20ml (266mg) of bupivacaine liposome was applied for ultrasound-guided bilateral pudendal nerve block.
Local Infiltration Group (LA Group).:10 ml of normal saline was used to dilute 266 mg (20 ml) of bupivacaine liposome to a total volume of 30 ml, which was divided into 6 equal parts for local infiltr
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients must meet all of the following criteria to be eligible for enrollment in this study: 1.Understand and agree to participate in this trial, and have provided signed informed consent; 2.Aged >=18 and =3 cm); 4. Body weight >=50 kg for males and >=45 kg for females; 5. Body Mass Index (BMI) >=19.0 and<= 30.0 kg/m²; 6. American Society of Anesthesiologists (ASA) Physical Status Classification of I to III.
Exclusion criteria
Exclusion criteria: Patients meeting **any** of the following criteria will be excluded from this study: 1. Patients with concurrent psychiatric disorders or cognitive dysfunction; 2. Patients with sensory disturbances such as hyperalgesia, or those experiencing other somatic pain that may interfere with postoperative pain assessment; 3. Patients with a history of myocardial infarction or unstable angina within the past six months, or a history of severe arrhythmias (e.g., second-degree or higher atrioventricular block); 4. Patients with diabetic peripheral neuropathy; 5. Patients with abnormal liver function: aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) and/or total bilirubin (TBIL) >=1.5× the upper limit of normal (ULN); 6. Patients with known allergies to bupivacaine or other amide-type local anesthetics; 7.Pregnant or lactating female patients, as well as patients planning to conceive within the next six months or unwilling/unable to use effective contraception; 8. Patients considered by the investigator to have any other conditions deemed unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS score for the most intense pain experienced during each bowel movement and dressing change within 3 days postoperatively; | — |
Countries
China
Contacts
Public ContactXu Hua
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed