nausea and vomiting
Conditions
Interventions
Opioid group:Administer sufentanil 0.4ug/kg during anesthesia induction
Less Opioid Group:Administer sufentanil 0.2ug/kg+ketamine 0.2mg/kg during anesthesia induction
No opioid group:Administer 0.4mg/kg ketamine during anesthesia induction
Sponsors
Taizhou Fourth People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Selection criteria 1. ASA classification: I-II level; 2. Age: 20-65 years old; 3.BMI:18-25kg/m^2 4. Non smoking female patients who require laparoscopic cholecystectomy 5. The patient and their family members are fully aware of and voluntarily cooperate with the anesthesia plan and study participation requirements for this examination.
Exclusion criteria
Exclusion criteria: Exclusion criteria Allergy to ketamine; History of severe PONV; Pregnancy or lactation period; Neurological disorders; Long term use of sedatives or hypnotics; Patients with moderate to severe hypertension and/or significantly elevated blood pressure will pose a serious risk; Refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of postoperative nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs at different time points during surgery;Operation time;Extubation time;First anal exhaust time;The highest postoperative pain score;adverse reaction;Recovery quality within 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactXinghuo Fu
Taizhou Fourth People's Hospital
Outcome results
None listed