Secondary hypogonadism in men
Conditions
Interventions
Group A:Receive standardized lifestyle intervention, including dietary guidance, exercise prescription, and behavioral modification, with pharmacotherapy when necessary, aiming for a 7–10% reduction i
Group B:Receive standardized lifestyle intervention, including dietary guidance, exercise prescription, and behavioral modification, combined with oral letrozole (2.5 mg),Once a week
Group C:Undergo standardized lifestyle intervention combined with oral testosterone undecanoate (40 mg, three times daily).
Sponsors
Anqing First People's Hospital Affiliated to Anhui Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Males aged 18–60 years; 2. BMI >=30 kg/m^2, or BMI >=28 kg/m^2 with central obesity; 3. Diagnosis of hypogonadism: at least two morning fasting serum total testosterone measurements < 12 nmol/L; 4. Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Non-obesity-related hypogonadism; 2. Severe cardiac, hepatic, or renal dysfunction; 3. Prostate cancer or suspected prostate disease; 4. Severe uncontrolled sleep apnea; 5. Current use of medications affecting sex hormone metabolism; 6. Mental disorders or inability to comply with the study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Total Testosterone (TT);Free Testosterone (FT); | — |
Secondary
| Measure | Time frame |
|---|---|
| Estradiol (E2);Luteinizing Hormone (LH);Follicle-Stimulating Hormone (FSH);Sex Hormone-Binding Globulin (SHBG);International Index of Erectile Function Questionnaire (IIEF-5);Aging Males' Symptoms (AMS) Scale;Metabolism and Body Composition, Including Fasting Blood Glucose, Insulin, Lipid Profile (Total Cholesterol, LDL, VLDL, HDL, Triglycerides, and Free Fatty Acids), and Glycated Hemoglobin (HbA1c);General Parameters: Including Blood Pressure, Heart Rate, Body Weight, Body Mass Index (BMI), and Waist Circumference; | — |
Countries
China
Contacts
Public ContactZheng Hailan
Anqing First People's Hospital Affiliated to Anhui Medical University
Outcome results
None listed