Knee Osteoarthritis
Conditions
Interventions
Knee Arthritis Observation Group:None
Sponsors
The Affiliated Hospital of Putian University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with end-stage knee osteoarthritis (Kellgren-Lawrence grade IV) who underwent unilateral total knee arthroplasty at Putian University Affiliated Hospital; 2. Age range: 18-80 years old; 3. No use of immunosuppressants or intra-articular injections for 6 months before the surgery; 4. Signed the informed consent form..
Exclusion criteria
Exclusion criteria: 1. Include rheumatoid arthritis, gouty arthritis, traumatic arthritis or infectious arthritis; 2. Severe liver and kidney dysfunction (Child-Pugh C grade / eGFR < 30); 3. History of malignant tumor; 4. Confirmed intraoperative cartilage calcification or extensive bone necrosis; 5. Refusal to provide tissue samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peptide length distribution;Protein molecular weight distribution;Distribution of protein coverage;Distribution of the number of peptides; | — |
Countries
China
Contacts
Public ContactShen Jianlin
The Affiliated Hospital of Putian University
Outcome results
None listed