Prostate surgery
Conditions
Interventions
Experimental group:At the end of surgery, a loading dose of 1 mg of Tigilidine was administered intravenously, and the patient-controlled analgesia (PCA) pump was started immediately. PCA pump setting
Control gruop:At the end of surgery, a loading dose of 3 µg of sufentanil was administered intravenously, and the patient-controlled analgesia (PCA) pump was started immediately. PCA pump settings: co
Sponsors
Shanghai Fengxian District Central Hospital
Eligibility
Sex/Gender
Male
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 50–85 years scheduled for elective transurethral prostate surgery under general anesthesia; 2. ASA class I–II; 3. Body mass index (BMI) >=18 kg/m^2 or <=30 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Oxygen saturation 10 days within 3 months prior to randomization; 6. Allergy or contraindication to opioids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting AUC24; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall incidence of urethral pain and incidence of moderate to severe pain within 48 hours postoperatively;;Resting AUC and Cough-induced AUC at 6, 12, and 48 hpostoperatively;;Richmond Agitation-Sedation Scale score;The usage of rescue analgesia;;Number of effective PCA pump demands within 48 hours postoperatively; | — |
Countries
China
Contacts
Public ContactLiu Rong
Shanghai Fengxian District Central Hospital
Outcome results
None listed