Perioperative cerebral oxygen management-related disorders associated with thoracoscopic surgery
Conditions
Interventions
Ciprofol Group:1. Anesthesia induction: Intravenous bolus of ciprofol 0.4mg/kg (injection >60s), simultaneous bolus of sufentanil 0.3µg/kg and cisatracurium besylate 0.15mg/kg (injection >20s). Loss o
the anesthesia maintenance protocol after thoracotomy is the same as the ciprofol group. 3. Position operation: The time and method of position conversion are the same as the ciprofol group, included
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, regardless of gender; 2. Scheduled for elective thoracoscopic lobectomy/wedge resection/segmentectomy; 3. ASA physical status classification Grade I-III; 4. BMI 18.0-30.0kg/m²; 5. Preoperative bilateral rSO2 >=65% (monitored by FNGINMED EGOS-600A); 6. Normal preoperative cognitive function (MMSE score: illiterate >=17 points, primary school education >=20 points, middle school education and above >=24 points); 7. Written informed consent signed by patients and their family.
Exclusion criteria
Exclusion criteria: 1. History of cerebrovascular disease (stroke, transient ischemic attack) or severe intracranial lesions; 2. Severe cardiopulmonary dysfunction (NYHA cardiac function Grade III-IV, FVC176µmol/L, blood urea nitrogen >7.1mmol/L, Child-Pugh Grade B and above); 4. Hypersensitivity to ciprofol, propofol, sevoflurane or cisatracurium besylate; 5. Use of sedative-hypnotics, opioids or antipsychotics within 1 week before surgery; 6. Forehead skin injury that cannot attach rSO2 probe; 7. Pregnant or lactating women, or those planning to become pregnant within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC of rSO2 deviation from baseline during induction to thoracotomy; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE scores at 6h, 12h, and 24h after surgery;Incidence of postoperative cognitive dysfunction;MAP values at T0-T8 time points;HR values at T0-T8 time points;Maximum decrease of MAP during induction to thoracotomy;Incidence of hypotension during induction to thoracotomy;Time to loss of consciousness;Total dosage of ciprofol/propofol during induction to thoracotomy;Dosage of vasoactive drugs during induction to thoracotomy;Incidence of injection pain during induction;Incidence of cough during induction; | — |
Countries
China
Contacts
Public ContactJingyan Lin
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed