postoperative cognitive dysfunction
Conditions
Interventions
Dextromethorphan group:Received a venous loading dose of dexmedetomidine (0.5 µg/kg within 10 minutes) followed by a maintenance infusion (0.2–0.7 µg/kg/h).
control group:Receive intravenous bolus infusion and continuous infusion of 0.9% normal saline at the same volume and rate
Sponsors
Zhengzhou Central Hospital Affiliated to Zhengzhou University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age:>= 65 years; 2. Planned major non-cardiac surgery, expected duration > 2 hours; 3. American Society of Anesthesiologists (ASA) classification I-III; 4. Normal cognitive function before surgery; 5. Signed informed consent to participate in the trial
Exclusion criteria
Exclusion criteria: 1. Previously diagnosed severe dementia; 2. Severe hearing/vision impairment preventing compliance with testing; 3. Severe liver and kidney dysfunction; 4. Long-term use of sedatives or antipsychotic drugs; 5. Severe cardiovascular disease (such as active myocardial infarction, decompensated heart failure) or severe arrhythmia without a pacemaker; 6. Stroke or traumatic brain injury causing unstable neurological function; 7. Inability to complete postoperative follow-up; 8. Allergy to dexmedetomidine;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality; | — |
Countries
China
Contacts
Public ContactQiong Song
Zhengzhou Central Hospital Affiliated to Zhengzhou University
Outcome results
None listed