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A randomized controlled study on the improvement of left ventricular remodeling and myocardial fibrosis in elderly patients with chronic heart failure through aerobic combined with blood flow restriction training under the first ventilation threshold

A randomized controlled study on the improvement of left ventricular remodeling and myocardial fibrosis in elderly patients with chronic heart failure through aerobic combined with blood flow restriction training under the first ventilation threshold

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600120352
Enrollment
Unknown
Registered
2026-03-12
Start date
2024-10-22
Completion date
Unknown
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic heart failure

Interventions

Intervention group:Aerobic combined blood flow restriction training

Sponsors

Beijing Friendship Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. meet the diagnostic criteria for chronic heart failure in the Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2018; 2. Those aged between 60 and 80 years old; 3. patients with NYHA class II-III were selected according to the cardiac function classification of the New York Heart Association (NYHA); 4. Left ventricular ejection fraction (LVEF) 30% to 49%; 5. patients who meet the WHO definition of cardiac rehabilitation in the 2007 U.S. Guidelines for Cardiac Rehabilitation and Secondary Prevention; 6. no visual and hearing impairment; 7. Voluntarily participate in this study and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. who have severe chronic heart failure or other reasons for limiting activity; 2. in the acute exacerbation phase of chronic heart failure; 3. Those with poorly controlled hypertension (systolic blood pressure >= 180 mmHg, or diastolic blood pressure >= 100 mmHg); 4. A resting heart rate of more than 120 beats/minute or a combination of malignant arrhythmia (paroxysmal ventricular tachycardia) with recent recurrence; 5. Combined with severe renal insufficiency and hepatic insufficiency; 6. Patients with severe chronic obstructive pulmonary disease, pulmonary heart disease or respiratory failure; 7. Combined with severe hematopoietic system, tumour and other serious primary diseases; 8. patients with combined psychosis, severe neurosis; 9. Patients with pregnancy status.

Design outcomes

Primary

MeasureTime frame
leftventricularmass;

Secondary

MeasureTime frame
Left ventricular ejection fraction;Myocardial fibrosis indicators;Peak oxygen uptake;Anaerobic threshold oxygen uptake;Minnesota heart failure quality of life scale;6 min walking test;

Countries

China

Contacts

Public ContactXie Ying

Capital Medical University, Beijing Friendship Hospital

zhangyichen1010@163.com+86 10 8160 9101

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 20, 2026